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Published on Feb 19, 2014
Table of Contents: 00:09 Lecture 2.1: Settling Time - Shape of a surface 00:25 Outline 01:01 Nanobiosensors have high sensitivity 01:51 Geometry is Important, but exactly how ? 02:57 Basic concepts: dimension of a surface 04:00 Classification of surfaces 06:18 Example: Regular 1D fractals 08:25 Regular and irregular 1D fractals 10:21 Dimension of quasi-2D Fractal 11:57 Same DF, but different geometry 12:44 Dimension of a irregular fractal surface 14:12 Irregular to regular surfaces 16:18 Outline 17:05 Settling time defines the fundamental limits of detection (Lectures 5-10) 19:14 Sensitivity defines transducer-specific limits of detection (Lectures 11-22) 20:40 Selectivity defines the practical limits of detection (Lectures 22-30) 22:00 Geometry is the key for nanobiosensing 22:58 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.