 I am Dr. Mitheshanti, Head of Department and Consultant, Department of Medical Genetics, Manipal Hospital. This department is 22 years old in Manipal Hospital. We are having in-house facility of counseling as well as a high-end genetic laboratory. So for the autism spectrum disorder, child psychologists, developmental pediatrician, pediatric neurologists and genetics, we work together as a team. Autism spectrum disorder is a neurodevelopmental disorder characterized by social environment, restrictive and repetitive behavior. The autism is a multifactorial condition where genetic and environmental cause plays a role in the etiology of the autism spectrum disorder. In the Center for Disease Prevention, CDC incidence of autism is 1 in 59, which is very high. The presentation of autism spectrum disorder is variable. The usual presentation is speech-delay, regression of developed milestone. But it can be identified as early as the third month of life when there is no social spine or there is no babbling at the age of 1 year. The other features are the repetitive movement and social skill deficit, likes to play alone, not to mingle with other children, hyperactivity and more boundless to objects. All those are the peculiar features of autism spectrum disorder. For genetic diagnosis, the chromosomal microarray is first line of investigation. There are more than 1000 genes which are associated with autism spectrum disorder and more than 2200 copy number variation. This chromosomal deletions and duplication has been reported in autism spectrum disorder. The other investigation which is required in the autism spectrum disorder is fragile screening and red syndrome screening in case of a female patient. And metabolic screening if the clinical features are indicated. Gene-level testing, so we have more than 1000 genes which is associated with the autism spectrum disorder, so that can be screened. In literature we know that the intervention if it is given before the age of 3 years it has more impact. Intervention is in the form of multiple techniques together physical therapy, occupational therapy, speech therapy and combination of medicine. This intervention helps in the children to develop their combinations and speech development. And if we identify the underlying genetic cause it can identify the other underlying genetic systemic abnormality. And once we identify the genetic theology it becomes easy to give the recurrences for the next pregnancy and we can help the family for the future pregnancy.