 This study found that the levels of inelukin-18, IL-18, are significantly higher in patients with systemic lupus erythematosis, SLE, compared to healthy individuals. Additionally, the levels of IL-18 are also significantly associated with the severity of renal involvement and disease activity in SLE patients. This article was authored by Muhammad Reza Jafari Nakjavani, Sema Abediyazar, and Babak Najadi.