 I had Dr. Siddhartha Mukherjee, post-surprise winner of Emperor Volmalities, the author. And he said, you have to remember, Sanjay, whatever disease you have, if it's like three sites, four sites, whatever the burden is, there is a replication index day to day and week to week, month to month that basically spits out all these variants, like kind of like COVID, but all these variations of mutations that could later down the road be that stop responding to therapy. When really it's that this new thing had come out there and is in show itself for 10, 12 months and everything else has died away and that is what you want to reduce as quickly as possible. And that really hit home with me because there's so many circumstances where even to get the genomic sequencing or the biopsy and stuff, people don't like me because I'm always like, we need to get this now and I'm trying to rush roll everything but that's because you want to treat things the soonest because you don't want that basically that variability factor to go any longer than you have to.