 This study aimed to estimate the prevalence of menstrual change and evaluate the association between COVID-19 vaccination and menstrual disturbances among 729 COVID-19 vaccinated women aged between 18 and 45 years in the Jezzan region of Kingdom of Saudi Arabia. The overall prevalence of menstrual change was 60.9% with most of the detected abnormalities related to delayed menstruation and changes in pain intensity. Menstrual disorders that occur after immunization are transient and have no long-term implications, but their effects are difficult to anticipate. Therefore, it is recommended to warn those concerned and encourage them to learn more about the biological changes causing these problems. This article was authored by Mahfuz Mohamed Saleh, Abdelmaj Mahamurtada, Al-Qasim Ahmad Wa'i and others.