 MIR-483-5P is a microRNA, MIRNA, that is expressed in the amygdala of male mice following exposure to stress. It has been shown to reduce anxiety-like behavior, and this effect is attributed to its ability to down-regulate the expression of three genes involved in stress-related processes, PGAP2, GPX3, and MAKF1. These genes are responsible for regulating the structure and function of dendritic spines, which are important for communication between neurons. MIR-483-5P also causes a decrease in the size of these structures, which further contributes to reduced anxiety-like behavior. Additionally, MIR-483-5P prevents the formation of immature philipodia, which are associated with increased anxiety-like behavior. Overall, MIR-483-5P is able to reduce anxiety-like behavior by altering the structure and function of dendritic spines and preventing the formation of immature philipodia. This article was authored by Marius Mutcher, Anna Escripeypeak, Jason B. Colanturi, and others. We are article.tv, links in the description below.