 Glioblastoma, GBM, is a highly aggressive form of cancer that spreads throughout the brain. It is composed of multiple different cell types, including astrocytes, neurons, and microleomyeloid cells. Three distinct tissue states have been identified based on how these cells interact with each other. The first state is characterized by high levels of astrocyte like mesenchymal glioma cells, reactive astrocytes, and macrophages. This state is associated with recurrent GBM and shorter survival. The second state is characterized by high levels of neuronal and microglial myeloid cells. This state is associated with lower recurrence rates and longer survival. Finally, the third state is characterized by low levels of all cell types. This state is associated with better outcomes. Inhibiting fatty acid synthesis in this state may be beneficial as it reduces the expression of genes associated with poorer outcomes. This article was authored by Osama Uldalama, Michael Giagenziano, Oditcha Kanan, and others. We are article.tv, links in the description below.