 Exosomes are small vesicles released by cells that contain important information about their identity and function. These vesicles have been shown to play a key role in cellular communication and have been implicated in many diseases. In this study, researchers investigated whether exosomes could be used as a tool to induce lineage-specific differentiation of stem cells. The team found that exosomes released by osteblasts, bone-forming cells, were able to induce lineage-specific differentiation of mesenchymal stem cells, MSCs. Furthermore, they showed that these exosomes could bind to matrix proteins like collagen and fibronectin, allowing them to be tethered to biomaterials. This suggests that exosomes may be useful in bone-regenerative medicine. This article was authored by Raguva and Narayanan,