 This study developed a novel method for creating customizable, thick, vascularized, and perfusable cardiac patches that match the patient's unique anatomy, immune system, and biochemistry. First, a biopsy of momentum tissue was taken from the patient and converted into pluripotent stem cells and cardiomyocyte and endothelial cells. Next, these cells were combined with a personalized hydrogel to create a bioink for the parenchyma and blood vessels. The resulting patches were then printed using a 3D printer and implanted into mice. The patches were found to be viable and capable of forming new blood vessels, which allowed them to be successfully transplanted into living animals. This study demonstrates the potential of this technique for creating personalized tissues and organs or for drug testing in an appropriate anatomical structure and patient-specific biochemical environment. This article was authored by Nadav Noor, Asaf Shapira, Ruvan Edri, and others.