 Context is an essential element of successful implementation and the implementation of evidence-based practices. It is difficult to define and pin down, but its importance cannot be overstated. This commentary highlights the need for further research on how context interacts with implementation and de-implementation, as well as the development of culturally sensitive understandings of context. Additionally, there must be continued investment into providing a more comprehensive list of determinants, which should be accompanied by the development of practical methods and tools to support their use and application. This article was authored by Joe Rycroft Malone, Lisa Rogers, and Christopher R. Burton.