 Hi, I am Dr. Yogesh Singh. I work as a consultant dermatologist at Manipal Hospital, Bangalore. No, a positive ANA does not always equate to a diagnosis of lupus, although almost all patients with lupus have a positive ANA. A positive ANA does not necessarily mean a diagnosis of lupus. ANA is positive in lot of other diseases. 5-30% of normal healthy individuals can have a positive ANA. Therefore, a positive ANA does not necessarily mean a diagnosis of lupus. Doctors have to consider other factors along with a positive ANA for a diagnosis of lupus.