 This study examined the prevalence of depression and anxiety among children with congenital adrenal hyperplasia, CAH. It was found that 12% of the children had mild depression and 9.1% had moderate depression. Additionally, it was observed that the total scores of the children's depression inventory, CDI, and Spence children's anxiety scale correlated positively with current age of the children, angiostinidium level, age at genitoplasty surgery, dose of hydrocortisone, and age at diagnosis. Furthermore, early genitoplasty surgery was a protective factor against the development of depression and anxiety, while disease chronicity with high glucocorticoid dose therapy was a precipitating factor for depression in these children. This article was authored by Sama Ahmed Hossanine, Nora Elzade Badwi, Dina Yousria-Fifi and others.