 Cancer is caused by the accumulation of genetic mutations, making it difficult to reverse. However, some studies have shown that cancer cells can revert back to normal cells under certain conditions. To better understand how this happens, researchers have developed systems biology approaches based on a tractor landscape analysis. These approaches suggest that a critical transition occurs during tumoragesis, leading to a new equilibrium state that is determined by complex intracellular regulations. This transition can be induced by combining intracellular molecular perturbation with external signals. Furthermore, a novel cancer aversion therapy approach has been proposed that could potentially replace current cancer cell-killing treatments. This article was offered by Don Quanchin and Quanchincho.