 This paper examines the relationship between risk and pleasure in the context of HIV prevention and care, focusing on the introduction of pre-exposure prophylaxis, PREP, among men who have sex with men, MSM. The authors argue that PREP has changed the landscape of HIV prevention and care, allowing for increased pleasure and safety while reducing the risk of contracting HIV. However, they also highlight the ambivalent nature of condomless sex, which can be seen as both risky and pleasurable. They further suggest that HIV prevention should not be viewed as a linear or predictable process, but rather as a complex, dynamic and ever-changing phenomenon. In doing so, they emphasize the importance of situational factors such as the interplay between humans and non-humans and the need to understand how various actors interact in order to best facilitate health outcomes. This article was authored by Luisa Augusto Vasconcelos de Silva, Sandra Cease Brazil, Felipe Mateo Estuarte and others. We are article.tv, links in the description below.