 In this study it was found that higher levels of electronic health, e-health, literacy were associated with lower rates of anxiety and depression among Nigerian adults during the COVID-19 pandemic. This suggests that e-health literacy could be used as a tool to help people cope with the stress of the pandemic. Additionally, the study showed that there were age, gender, and regional differences in the associations between e-health literacy and psychological outcomes. These findings suggest that tailored interventions should be developed to address the needs of specific groups. This article was authored by Al-Uwadamilir-Akingbaid, Al-Uwadamilir-Akingbaid, Khatajat Adalai, and others.