 Abstract chemodynamic therapy, CDT, is a new treatment method that uses hydroxyl radicals, OH, to target cancer cells while leaving healthy cells unharmed. This makes CDT a safe and effective way to treat cancer. In order to make CDT more efficient, researchers have developed a combination of NH2, MIL, 101, FE, a FE-based MOF, and D-Penacillamine, D-PEN, a copper chelating agent. When injected into cancer cells, these two components work together to produce OH, which kills cancer cells but leaves healthy cells alone. Additionally, they can be used in conjunction with chemotherapy drugs like CPT-11 to further enhance their effectiveness. In animal studies, this combination has been shown to be the most effective at treating cancer. This article was authored by Han by Ji, Cho Rim Kim, Chan He-Min, and others.