 This study evaluated the effects of sub-gingival delivery of 0.8% hyaluronic acid, HA, gel on periodontal health in patients with chronic periodontitis. The results showed that HA gel had a positive effect on periodontal health, reducing gingivitis, bleeding on probing, probing pocket depth, and clinical attachment level. Additionally, it reduced levels of pro-inflammatory cytokines such as interleukin-1 beta and tumor necrosis factor alpha, as well as biomarkers of inflammation such as seriactive protein and alkaline phosphatase. These findings suggest that HA gel may be an effective adjunct to scaling and root debridement for treating periodontitis. This article was authored by Chena Anwar Muhammad, Barzan Abdul Wahab Mirza, Zainab Saleem Mahmoud, and others.