 this study examined the transcriptomic profile of hand-cellular polymorphous cells shifted from glucose to methanol. It found that nearly 20% of the genes were upregulated, including those encoding transcription factors, formate dehydrogenases, and enzymes of the methanol metabolism pathway. Additionally, the expression of peroxisomal oxidation genes was increased, as well as the expression of autophagir-related genes such as ATG-8 and ATG-11. Furthermore, the expression of genes involved in glycolysis and translation was decreased, suggesting that these processes are not necessary for growth on methanol. Overall, this study provides insight into how hand-cellular polymorphous cells adapt to methanol as a sole source of carbon and energy. This article was authored by Kipers-Oscopy, De Jong-An, Susanna Kim-A, and others.