 Epicaparomics is a new approach for identifying and studying protein-protein interactions, PPI's. This technique uses chemical binders called epicaparomes to probe PPI's in native cells and tissues. By taking advantage of this technology, researchers can gain a better understanding of how PPI's are affected in diseases such as cancer. Epicaparomics has been used to identify PPI dysfunction in cancer cells, providing valuable insight into the underlying mechanisms of cancer cell growth. Additionally, epicaparomics has been shown to be effective in restoring normal PPI function in cancer cells, suggesting potential applications for targeted therapies. This article was authored by Anna Rodina, Chaoshu, Chanda S. Dickwall, and others.