 Throughout human history there have been numerous examples of the application of chemical and biological agents used as weapons during the course of warfare. In the 20th century, their devastating potential has become apparent to terrorists. And although there have been many global efforts to restrict chemical, biological, radiological and nuclear materials, the emergence of CBR and E-terrorism has become a significant threat, requiring immediate attention and a call for collective action. Terrorism is evolving to the changes in our socio-political environment. Our political history, our technology, the way we communicate. And these changes have led that terrorist organizations and individuals have changed the way they operate, the way they acquire funding and deploy capabilities beyond our imagination. These factors place a priority on the need for law enforcement to be aware of all of the issues, be better equipped to deal should a catastrophe happen and to do so by playing a leading role in the cooperation between multi-agencies. In dealing with CBR and E- incidents, we all have to work together. And it's quite often the case that it's law enforcement who has that coordination role between all multi-agency partners. As the global law enforcement entity, Interpol is moving towards the forefront of the global response on all forms of terrorism by assisting member countries in the prevention and disruption of terrorist activities through identifying members of known transnational terrorist networks and their affiliates. This is done by tackling the main enabling factors of their activities, travel and mobility, online presence, weapons and materials and finances. The CBR and E-subdirectorate forms part of the weapons and materials segment of a broader counter-terrorism strategy. Its methodology for countering the threat of CBR and E consists of three main pillars. Information sharing and intelligence analysis, capacity building and training and operational and investigative support.