 This study examined the relationship between gene mutation and protein activity in cancer cells. The researchers found that while many mutations were associated with increased protein activity, this was not always the case. Instead, they observed that compensatory mechanisms often occurred when a mutation caused a decrease in protein activity. Additionally, the researchers identified proteins whose activity was most affected by different types of cancer and found that these proteins could be linked to differences in patient survival. This study provides valuable insight into the role of protein activity in cancer development and progression. This article was offered by Abel Souza, Aurelian Dugard, Danish Mayman, and others.