 This research paper discusses the use of unmanned aerial systems, UAS, for mapping the spatial distribution of weeds in a cornfield. It also outlines a process for creating a prescription map based on the mapped weed distribution and then using a commercial-sized sprayer to apply the prescribed amount of herbicide to the field. By using this process, the researchers were able to save 26.2 percent of the total area from being sprayed with herbicide, compared to the current method of uniformly distributing herbicide throughout the entire field. This article was authored by Ron John Sapkota, John Stenger, Michael Ostley, and others.