 Thank you very much. I'm incredibly grateful to Walter who's just explained the tumor to you in detail saving me a great deal of work Thank you, Walter I'm even more grateful to the Brain Foundation. It's a it's a real honor to be here and The weather is certainly better than in Melbourne. So that's a plus, too I Want to tell you a bit about what it means for me to receive a gift of this sort From this organization and what that means in terms of progressing my research Now I'm training to be a neurosurgeon and in the course of my work in hospitals around Australia. I Have become increasingly just just made and distressed By the following scenario. So I want you to imagine It's two in the morning in the emergency department and I've been called to see a patient who's come in with a headache And they've had a seizure or a funny turn and the whole family is there and everyone's really distressed And in their hands, they're clutching this packet And it's a scan that the GP has organized and I open up that packet and I have a look at it And there's a lump in the brain And when I see that lump my heart sinks because I know that there is nothing good that looks like that on a scan And I know that if this is an aggressive tumor if it is a glioblastoma Then this is the lump that will limit my patient's life So then I go through the process of explaining to them What it is that we can do for them in the next days weeks and months and you've had some of that described to you already But I know that what we're able to offer them is not enough And I've watched my colleagues in other tumor streams people working in breast cancer or Melanoma have wonderful breakthroughs with amazing new biological treatments for these cancers And I've seen them shift the dial for their patients and more than anything else. I want that for my patients So I've embarked on a journey of learning to be a scientist not just a surgeon because as you've already heard This isn't the surgical disease the answers are in the lab So my work focuses on a protein called the epidermal growth factor receptor This protein lives on the surface of cells and in normal cells it helps them to grow and develop in brain tumor cells it can be Over-expressed there can be too much of it. It can be improperly folded can have mutations and in those cases It can be driving the cancer And so what we are focusing on in my lab and it is a lab that has a lot of expertise with this receptor and has Contributed to significant breakthroughs in EGFR structure and function in the past is we're actually having another look At the structure in light of some of the novel agents that have arisen some of these small molecule agents some of the immunotherapies That have become available ways of hijacking the cells equipment to kill the cell And we're isolating this receptor on little tiny slips of Basically a little bit of lipid with a little ring around it called nanodisks So that we can have a look at those receptors in detail And then see what happens to the structure of the receptor as we add combinations of Different agents that are available At the end of the day what we'd like to be able to do is to stop these cancer cells from growing And if we can kill those cancer cells then my patients will get to live so thank you for your help with that