 This paper proposes a novel hippocampal E.C. neuronal network model to explore the mechanism of epileptic generation. The model demonstrates how increased excitability of pyramidal neurons in C.A.3 can drive the hippocampus and entorhinal cortex to produce a transition from background to seizure states, resulting in exaggerated phase amplitude coupling, PAC, phenomenon of theta-modulated high-frequency oscillations, HFO. This PAC phenomenon can be used as a potential marker of seizures. Additionally, the model suggests that increased synaptic connectivity between mossy cells and granule cells and pyramidal neurons in C.A.3 can generate epileptic discharges. Furthermore, the model shows that hyper-excitable stellate cells in the entorhinal cortex can lead to seizures, supporting the idea that the entorhinal cortex can act independently as a source of seizures. This article was authored by In Yu, Feng Han, and Qing Yun Wang.