 Tumor-captobenzimidazole, 2MBI, analogs were synthesized as potential tyrosinase inhibitors due to their ability to bind copper ions at the active site of tyrosinase, and nine of these analogs showed submicromolar IC50 values for mushroom tyrosinase monophenylase activity. The tumor-captose substituent plays an important role in tyrosinase inhibition, and the 2MBI analogs exerted potent antioxidant effects against various reactive oxygen species. These results support the potential use of 2MBI analogs as anti-browning agents in foods such as mushrooms, vegetables, and fruits. This article was authored by Jin Li, Haisu Park, Hee Jin-young, and others.