 The systematic literature review assessed the immunogenicity, efficacy, and safety of a purified chick embryo cell culture rabies vaccine, PSEC-VCVE, for post-exposure prophylaxis, PEP, against rabies by intramuscular or intradermal administration. The meta-analyses showed that almost all individuals had rabies virus-neutralizing antibody titers above the World Health Organization recommended serological threshold after starting PEP with PSEC-VCVE, and the vaccine had an acceptable safety profile. However, improving access to PSEC-VCVE for PEP against human rabies remains a challenge due to the high number of annual deaths from the disease. This article was authored by Scott Price, Ponthak Chanthavanich, Lin H Chen, and others.