 curve is something which we have been using the term. So, this is Professor Kool and she has given those kind of curves and description and we on and off use it for the contrast enhance breast MRI. So, in the morning, Shilpa Ladman also told about the same and even ORADS we saw that dynamic evaluation with post contrast is important. So, basically you have to put in contrast dynamically you have to evaluate multi-phasic MR sequences and the early uptake is important followed by what happens to the contrast kinetics later on. So, two parts we have to see. So, there are three kinds of curves type 1, type 2, type 3. Type 1 curve is slow increase and persistent enhancement. So, this is very common with your benign lesions. So, only less than 9 percent of lesions are malignant and they have this curve. So, basically type 1 curve is towards benign entities. We are using this on and off for breast MRs contrast enhance breast MRI, but also again can be put up in other scenarios as well. Type 2 is plateau phase. So, initial uptake is there followed by a plateau phase. So, the uptake will be as compared to a normal area of the breast the uptake will be little early, but later on it will be like a plateau. So, that is again concerned for malignancy more than type 1, but less than type 3. So, most of the time these are benign lesions only and the last is type 3 the ones which we are concerned about the washout pattern. So, rapid uptake and rapid washout. So, that is a feature of neo angiogenesis pattern which is a pattern of malignant lesions. So, 29 to 77 percent chances of malignancy, but again if you see the percent is quite low. So, it is not sensitive not specific this is just an add-on as in the morning also we saw that morphology over enhancement pattern. So, you have to see the morphology first and then correlate the enhancement kinetics. So, we have to talk about two things slow, medium, fast initial uptake that is the first two minutes are important ideally 60 to 75 seconds and later on what is happening to that whether it is washing out or it is plateauing or it is persistently slowly enhancing and this is the angle theta which we were talking about in the morning also. So, this angle higher greater the angle that means faster is the uptake. So, rapid uptake is more towards the malignant side. So, type 3 curve. So, scan protocol wise you have to inject the contrast fast most of the centers still have hand injection which is fine because the amount of contrast in MR is not very much which we are giving, but the acquisition has to start quick and the first phase has to be within 60 seconds which you have to acquire and then multiple phases ideally 8 to 10 phases should be acquired and where do you place these region of interest ROIs. So, when you are documenting you have to place it at 4 places which is the lesion where you want to show what kind of activity or enhancement kinetics is there other area is a normal breast parent chimera to show the comparison. Third is air that will be a control means just like it is not a wrong analysis. So, it should be a flat curve when you are placing it in the air area and the fourth place is the heart or aorta just to show again a control. So, proper contrast injection has happened that will be picked up with this ROI in the aorta or in the cardiac chambers. So, basically three more important places and one in there as a control will give you ideal graphs and then you can comment upon the enhancement curves. So, this was about the cool's kinetics curve.