 TISP-40 is a transcription factor that is activated during periods of endoplasmic reticulum stress, such as during cardiac ischemia or reperfusion, IRR. It is involved in regulating the hexo-salmon biosynthetic pathway, HBP, which produces eudyne diphosphate and acetylglucosamine, UDP-GLC-NAC, for O-linked GLC-NAC, O-GLC-NAC, protein modifications. This process helps cells survive lethal stresses, and when it is disrupted, can lead to cardiac damage. TISP-40 also has a role in regulating the unfolded protein response, UPR, which is triggered by endoplasmic reticulum stress. When this occurs, TISP-40 is released from the endoplasmic reticulum and enters the nucleus, where it binds to a specific DNA sequence called a UPIE, and increases the production of proteins needed to repair damaged cells. By increasing the levels of these proteins, TISP-40 protects against cardiac IRR injury. This article was authored by Xin Zhong, Ken Hu, Zhen Guo Ma, and others. We are article.tv, links in the description below.