 The widespread prevalence of diabetes is due to impairment of insulin secretion and insulin resistance. This can be treated with glucagon like Peptid-1, GLP-1, which stimulates insulin secretion from beta cells. Recently, prolonged activation of the GLP-1 signal has been shown to reduce diabetes in both animal and human subjects. Coffee polyphenol extract, CPE, has also been found to lower diabetes risk, suggesting that CPE could potentially stimulate GLP-1 secretion. In this study, CPE was found to increase GLP-1 secretion in human enteroendocrine NCI H716 cells, as well as in mice. Additionally, CPE increased intracellular cyclic AMP, CAMP, levels, that this was not mediated through G-protein coupled receptor 119, GPR119. Oral administration of CPE also increased diet-induced active GLP-1 secretion and decreased post-prandial hypoglycemia, indicating that higher GLP-1 levels after being. This article was authored by Yoshifuji, Noriko Osaki, Tadashi Hayes, and others.