 This review provides a critical assessment of the current understanding of silver nanoparticle toxicity, highlighting the challenges in elucidating mechanisms of interaction and modes of action due to the complex nature of nanoparticles. The authors emphasized the need for detailed descriptions of nanoparticles, their synthesis root, coating, and evolution under exposure conditions to enable comparisons and predictions of toxicity. They also raise concerns about overuse of nanosilver and potential bacterial resistance. The review concludes with a call for a risk-benefit analysis and restrictions on uses where a clear benefit cannot be demonstrated. This article was authored by Assault Lynch, Kenneth A. Dawson, Andreas Lech, and others. We are article.tv, links in the description below.