 The PREP-1519 study was developed by a multidisciplinary team of researchers from different institutions and areas, including adolescents and young adults. It aimed to evaluate the effectiveness of PREP in real-world settings and to assess its acceptability, uptake, use, and adherence among adolescents and young adults. Additionally, comprehensive services and friendly environments were implemented in the clinics, allowing for a more holistic approach to the study. Through this collaboration, the study was able to gain insights into the direction of the research, as well as the communication process between cultures and languages. This article was authored by Ines Dourado, Leo Magno, Dursa Bartolomegreco, and others.