 In wound management, the control of infections represents a crucial issue in a multi-billion-dollar industry worldwide. The greatest barrier to healing is represented by the biofilm, an organized consortium of bacteria encapsulated in a self-produced extracellular polymeric substance. There's an urgent need for novel anti-biofilm strategies and novel antimicrobial agents. Silver nanotechnology has received tremendous attention in recent years in therapeutically-enhanced healthcare. This article was authored by Federica Paladini and Maro Polini.