 This study has demonstrated that interferon-gamma, IFN, is a potential therapy for immunosuppression of sepsis, promoting glycolysis to restore metabolic defects in monocytes, and the mechanism of treatment is unclear. This study has shown that IFN promotes the Warburg effect through the PI3K ActMTOR pathway to reverse the immunosuppression caused by sepsis. This provides a new target for the treatment of sepsis. This article was authored by Xu Zhifu and Yu Wang.