 The clinical sequencing evidence generating research, CSER, consortium is a multidisciplinary collaboration of researchers from different institutions who aim to develop and implement new methods for using genetic sequencing in clinical care. The consortium faced several challenges, including the complexity of the technology, the need for expertise and coordination among various medical specialties, uncertainty about clinical utility, and potential societal implications. To address these challenges, the consortium used transdisciplinary approaches, such as collaborative team science and consortium-wide harmonization of measures. Additionally, funding agencies can help consortia by clarifying key study design elements and providing frameworks for data sharing. This article was authored by Katrina A. B. Goddard, Frankeian Angelo, Sarah L. Ackerman, and others.