 This study assesses the data availability, accuracy, and concurrent validity of vital sign data measured with wearable sensors and volunteers during various daily life activities in a simulated free-living environment. The results show that vital patch was found to be the most accurate and valid for vital signs monitoring, while Iverian had a small mean difference with large LOA for RR, underestimated SPO2, greater than 1%, and overestimated temperature up to 2.9 degrees Celsius. This article was authored by Marjolean Ehaveman, Matilde C. van Rossum, Raswita M. Iveser, and others.