 Giulio Pompilio scientific director, Centro Cardiologico Monzino full professor of cardiac surgery University of Milan. Organoids today are not only no longer a nice lab toy. They represent a very promising tool for drug discovery and personalized medicine. They offer new opportunities in toxicology studies, in those findings studies mimicking organs and tissue, even better than organon chips. They also represent a very promising tools in clinical trials offering a perspective in personalized drug identification and response during the trial for adjusting therapies and diagnostics. And finally they also offer opportunities for biomarkers discovery. So in the cardiovascular space organoids which are called cardioids mimic better and better like mini hearts. And I think especially in genetic cardiomyopathies they offer unique opportunities for development studies for understanding of new mechanisms but also for testing new drugs or old drugs for specific patients. Research today is of course an international competition. I think it's compulsory to have international collaborations for centers of excellence as Monzino for example are. I think opportunities like these meetings are very important to know what people is researching outside and link up with the best centers. I think there are opportunities Italy it's a place where young people are very passionate research and they spend time and also talent for in the lab and for example in research hospital like we are. The strengths are the system itself. We need to learn more how to link up and coordinate efforts first of all and second as everybody knows fans, public fans are one of the major constraints we have because I think Italy is not investing enough in the future. Which is and research is one of the main streams for developing the countries.