 Recent advancements in drug delivery technologies utilizing a variety of carriers have opened up new possibilities in the field of medicine. Mesoporous silica nanoparticles, MSNs, are one such promising material that has gained much attention due to its unique characteristics. MSNs can be easily synthesized from a simple process, making them cost effective. Furthermore, they can be tailored according to the desired morphology, pore size and volume, and particle size. This makes them highly adaptable and suitable for a wide range of applications. Research into MSNs has increased significantly in recent years, leading to their use in drug delivery systems for treating various diseases. Additionally, MSNs have been found to be useful in drug-resistant chemotherapy and antimicrobial therapies. In this review, we discussed the synthesis of MSNs and their applications in drug delivery systems. We also highlight the limitations of MSNs and the need for further research to fully understand their interactions with biological systems. Finally, we summarized the patents related to MSNs for therapeutic purposes. This article was authored by Rieman Orion, Lusha Wainayak, Ashok M. Raichur and others. We are article.tv, links in the description below.