 As we know, brain disorder is the most common disease in human beings. It is characterized by the high problems and the enormous burden of disease with the significant impact on the development and the disability and the quality of life. There were so many types of the brain disorder in the children, epilepsy, autism, ADHD, and currently there was no effective treatment for the most of them. Most of the brain disorders is genetic. So, recently, the Nest Generation Sequency Technology provided the unprecedented opportunity for the diagnosis of disease. $500 for the whole excel and the $1,000 for the whole genome. The pass of the new disease gene is increased dramatically and that's provided the genetic diagnosis. In the clinic, we just used the SEG and the neuroimaging technology to guide the precision resection of the epileptogenetic lesions. So, based on the genomics and the neuronetwork, we further understanding the pathogenesis and the mechanism of the brain disorders to find and the searching screen in their new treatment. We also conducted some of the mental biologics analysis through the NMR and to study the influence of the gut microfoil on the brain function in the patients with the ketogenic doubt. And also, we are developing some variable device for the real-time monitoring of brain function and to look for some remote medical alert on the internet technique-based AI. So, with multi-disciplinary treatment and research, the new target drug and the neuromodulation and the robotic surgery, ketogenic doubt, gene therapy, all of the comprehensive therapy provide the precision medicine. And also, we study the gene function and the gene mutation and the function of the proton and selected different target drug according to the function of the gene such as lost function and the gear function and to supply the offered the precision medicine. The new technician such as the gene therapy and the molecular therapy to have entered the new era. And we also provide these new technicians in the clinic practice and to improve our treatment. And so, in clinical practice, they will at least deny neuro-metabolic disease can be cured by the enzyme replacement therapy. That means some disease-revealed treatable disease can be with the specific molecular therapy. So, embryonic stem cells and induced polypotent induced stem cells provide the opportunity to repair the brain disorder and the brain damage. In summary, the development and the clinical application of the new advanced science and technology to give us a broad way to improve the level of the treatment. So, new technology and the new hope. We believe we can make big progress and to offer millions of patients the hope to come. Thank you very much.