 Bone regeneration has become increasingly important in modern medicine due to the prevalence of bone diseases and injuries. Recent advances in tissue engineering have led to the development of novel approaches for bone repair, including the use of scaffolds combined with live osteoblast progenitor cells, such as mesenchymal stem cells, MSCs. These scaffolds can be made from various materials, such as calcium phosphate ceramics, biphasic calcium phosphate bio-ceramic granules, and organic bovine bone. Additionally, MSCs can be expanded in good manufacturing practice, GMP, facilities using human platelet lysate, PL, as a supplement without osteogenic factors. Several clinical trials have been conducted to evaluate the safety and efficacy of these approaches, with promising results. However, more research is necessary to optimize the clinical application of these techniques. This article was authored by Federica Ri, Alisa Borsani, Rita Rizzani, and others. We are article.tv, links in the description below.