 This study analyzed mHealth related literature published between 2000 and 2020 from the Web of Science Database to determine future research direction in mobile health, mHealth. The results showed an exponential growth trend in the number of annual publications in mHealth literature, with the United States being the leading contributor. The study identified five clusters of keywords co-occurred by top 100 authors and revealed a gradual shift in mHealth research from health policy and improving public health care to the development and social application of mHealth technologies. This article was authored by Jianfei Chao, Yongja Lim, Shintaro Sengoku, and others.