 Polymeric micelles are self-assembling nanoconstructs of amphiphilic copolymers with a core shell structure. These micelles have gained immense popularity due to their favorable properties such as the ability to solubilize a variety of poorly soluble pharmaceutical agents, biocompatibility, longevity, high stability in vitro and in vivo, and the ability to accumulate in pathological areas with compromised vasculature. Additionally, they can be engineered with various ligands and cell-penetrating moieties to allow for specific targeting and intracellular accumulation, respectively, to load them with contrast agents to confer imaging capabilities and incorporate stimuli-sensitive groups that allow drug release in response to small changes in the environment. There has been an increasing trend towards designing polymeric micelles which integrate a number of the above functions into a single carrier to give rise to smart, multifunctional polymeric micelles. Multifunctional micelles can be envisioned as key to improving the efficacy of current treatments which have seen a steady increase not only in hydrophob. This article was authored by a DDM Gevary and Vladimir P. Torchlin. We are article.tv, links in the description below.