 This study examined the factors influencing pox vaccination uptake during the COVID-19 pandemic. It found that communication, stigma, accessibility to and availability of vaccines, and concerns about vaccine safety are all important factors in people's decision making when it comes to getting vaccinated. Additionally, the study suggests that a social media-based risk communication plan should be implemented to address vaccine mistrust and disinformation. Furthermore, measures should be taken to remove logistical barriers to vaccination, such as providing more accessible locations and increasing the number of available vaccines. Finally, obtaining fact-based information from credible sources can help improve public confidence in the vaccine. This article was authored by Priya Bratrajkova, Biola Sadie D'Souza, Rush Miquerel, and others.