 Cell membrane-coated poly, lactic-coglycolic acid, PLGA, nanoparticles, N-piece, are being increasingly used as vehicles for delivering drugs due to their favorable biocompatibility and ability to provide controlled drug release. Recent advancements in this field include the development of N-piece camouflaged within cell membranes, which can be used to extend circulation times, target-specific cells, and bypass physiological barriers. This review summarizes these developments and outlines potential applications of cell membrane-coated PLGA N-piece in the areas of cancer therapy, inflammatory diseases, cardiovascular disorders, and infectious diseases. Challenges associated with the use of cell membrane-coated PLGA N-piece are also discussed, along with suggestions for future research. This article was authored by Nasrullah Jan, Asadullah Madni, Safiella Khan, and others.