 This study examined the experiences of front-line nurses caring for patients during the first six months of the COVID-19 pandemic. Six key themes emerged from the data, including emotional experiences, physical symptoms, ethical and moral challenges, professional impact, risk factors for negative emotional experiences, and protective factors for future pandemics. The findings suggest that front-line nurses are facing significant challenges during the pandemic, and that providing them with adequate resources and support can help ensure they remain in their chosen professions. This article was authored by Megan R. Jackson, Joanne Porter, and Christopher Masanio.