 The SARS-CoV-2 virus has been rapidly evolving since its discovery in late 2019. This rapid evolution has led to the development of multiple mutations in the virus's RNA-dependent RNA polymerase, RODRP, which is responsible for replicating the virus's genetic material. In particular, eight new mutations have been identified in the RODRP gene, which are predominant in Europe and North America. Additionally, a silent mutation was found in the UK on February 9, 2020, while another mutation was discovered in Italy, Lombardi, on February 20, 2020. These mutations may contribute to the virus's ability to evade host immunity and develop drug resistance. Furthermore, the presence of these mutations could potentially lead to different mortality rates among individuals infected with the virus. This article was authored by Maria Pichetti, Bruna Marini, Francesca Bernadetti, and others.