 This study assessed the effectiveness of a targeted intervention using a collaborative approach added to a comprehensive educational intervention to reduce the inappropriate use of oral third-generation cephalosporin, 3Gc, antibiotics. The intervention was introduced into two departments with high rates of 3Gc prescriptions, ophthalmology and dermatology. The results showed that the targeted intervention reduced the number of days of treatment of 3Gc's by 13.48 dot per 1000 patient days in inpatients and 0.69 dot per 1000 outpatient visits per month. This suggests that the targeted intervention may be effective in reducing inappropriate use of 3Gc's. This article was authored by Ryo Yamaguchi, Ko Okamoto, Takihito Yamamoto, and others.