 pyruptosis is a type of programmed cell death, PCD, that is triggered by the activation of inflammatory soams. It is characterized by the release of pro-inflammatory cytokines and other contents from the dying cells. This process is important for the maintenance of homeostasis and embryonic development. Recent research suggests that pyruptosis may play a critical role in various inflammatory diseases such as cardiovascular diseases, cancers, neurological diseases and metabolic diseases. In particular, it has been found that pyruptosis is involved in the pathogenesis of many inflammatory diseases. Therefore, targeting pyruptosis could be a promising therapeutic approach for the treatment of these diseases. This article was authored by Siong Yujin, Yintu Ma, Didi Liu and others.