 The cell layer eliminates unwanted cells through the extrusion process, which is driven by both cell-cell and cell-substrate interactions. The extrusion process is controlled by the balance between these two forces, which can be adjusted independently to control the number of extrusions. Increasing the relative strength of cell-cell adhesion leads to more extrusions, while decreasing it leads to fewer extrusions. This allows the cell layer to switch between different types of defects, depending on the amount of cell-substrate adhesion. Furthermore, the extrusion process can act as a mechanism to relieve localized stress concentrations, resulting in a more uniform distribution of stresses throughout the cell layer. This article was authored by Sivosh Manfred, Guru Swami Ravachandran, Hosea Andrade and others.