 The study examined the effects of deleting two genes, EAF-1 and EAF-2, on hypoxia tolerance in zebrafish. The results suggest that these genes play an important role in the development of erythrocyte production during hypoxic conditions. Specifically, the study found that the absence of EAF-1 and EAF-2 resulted in decreased hypoxia tolerance due to reduced erythropoiesis. Furthermore, the study also observed alterations in the expression of certain genes involved in epigenetics and WNT, catenin signalling pathways. This suggests that EAF-1 and EAF-2 may be involved in the regulation of gene expression, through epigenetic mechanisms and WNT, a catenin signalling pathway. This article was authored by Wenyu Liu, Xu Huilin, Lingwei Li, and others.