 Genomic testing provides broad reaching and early, albeit complex, uncertain, and shifting, prognostic information. As genomic testing occurs earlier and increasingly in a screening context, researchers and clinicians must strive to understand and manage the prognostic implications of results. While our understanding of the psychosocial and communicational aspects of prognosis in symptomatic populations is incomplete, it has progressed further than our understanding in a screening context and therefore provides useful lessons and feasible opportunities for further research. This article was authored by Rebecca Mueller, Brittany M. Lee, and Catherine Press Callaghan.